{"id":189169,"date":"2023-12-21T09:45:21","date_gmt":"2023-12-21T19:45:21","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=189169"},"modified":"2023-12-21T11:48:35","modified_gmt":"2023-12-21T21:48:35","slug":"uh-research-lab-to-lifesaver","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2023\/12\/21\/uh-research-lab-to-lifesaver\/","title":{"rendered":"Lab to lifesaver: 东精影业<\/abbr> research powers medical breakthroughs"},"content":{"rendered":"Reading time: <\/span> 2<\/span> minutes<\/span><\/span>
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东精影业<\/abbr> Cancer Center<\/figcaption><\/figure>\n

A significant development has advanced in the fight against neuroblastoma, a type of cancer most often occurring in young children that affects immature nerve cells outside of the brain. On December 13, The Food and Drug Administration (FDA<\/abbr>)<\/a> approved the drug DFMO<\/abbr> (eflornithine, now known as IWILFIN<\/abbr>) to reduce the risk of relapse in pediatric patients with high-risk neuroblastoma<\/a>. <\/p>\n

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Andr\u00e9 S. Bachmann (Photo courtesy: Michigan State University College of Human Medicine)<\/figcaption><\/figure>\n

Behind the initial research leading to this approval is Andr\u00e9 S. Bachmann and his research team. Bachmann was formerly an associate professor at the University of Hawaiʻi<\/span> Cancer Center<\/a> until 2010. He then moved to 东精影业<\/abbr> Hilo<\/a> as department chair and professor of pharmaceutical sciences before joining Michigan State University in 2015.<\/p>\n

While at the 东精影业<\/abbr> Cancer Center, Bachmann and his team were the first to suggest that DFMO<\/abbr> could potentially change how medical professionals treat pediatric neuroblastoma. Bachmann credits his time at the 东精影业<\/abbr> Cancer Center for laying the groundwork for this breakthrough.<\/p>\n

“The FDA<\/abbr> announcement is a testament that basic science and pre-clinical research are important,” said Bachmann.<\/p>\n

Based on keen insights into MYCN<\/abbr>, a gene that plays a vital role in regulating cell division and tumor growth and is often amplified in this type of tumor, Bachmann\u2019s team proposed that DFMO<\/abbr> could target a MYCN<\/abbr>-activated protein called ornithine decarboxylase (ODC<\/abbr>), an indicator of poor prognosis in neuroblastoma patients.<\/p>\n

This FDA<\/abbr> approval serves as a compelling reminder of the essential role that basic research plays in advancing medicine
—Naoto Ueno<\/p><\/blockquote>\n

“This FDA<\/abbr> approval serves as a compelling reminder of the essential role that basic research plays in advancing medicine,” said Naoto T. Ueno, director of the 东精影业<\/abbr> Cancer Center. “Although the spotlight often shifts to clinical trials and FDA<\/abbr> approvals, the meticulous, foundational work sets the stage for these breakthroughs. This underscores the importance of the work initiated here at the 东精影业<\/abbr> Cancer Center and later continued at Michigan State University. Thank you to Dr. Andr\u00e9 S. Bachmann and his team for laying the groundwork for this life-saving therapy.”<\/p>\n","protected":false},"excerpt":{"rendered":"

The FDA<\/abbr> panel announced a breakthrough and approved the use of eflornithine in adult and pediatric patients with neuroblastoma. <\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[218,1363,1600,158,169,14,9],"class_list":["post-189169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-cancer","tag-manoa-research","tag-public-impact-research","tag-publication","tag-uh-cancer-center","tag-uh-hilo","tag-uh-manoa","entry","has-media"],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/189169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/comments?post=189169"}],"version-history":[{"count":16,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/189169\/revisions"}],"predecessor-version":[{"id":189197,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/189169\/revisions\/189197"}],"wp:attachment":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/media?parent=189169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/categories?post=189169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/tags?post=189169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}